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Evgeny Davidovich Sverdlov(b. November 16, Dnepropetrovsk, Ukrainian SSR, USSR) - Soviet and Russian biochemist, professor, corresponding member of the USSR Academy of Sciences (December 26), Academician of the Russian Academy of Agricultural Sciences (), full member of the Russian Academy of Sciences (May 29), Doctor of Chemical Sciences.

Biography

• Father - David Immanuilovich Sverdlov - an employee of the Central Committee of the Communist Party (b)U; mother - Yudif Markovna- School teacher.
• In 1955 he graduated from high school with a silver medal in the Stavropol Territory, where he was evacuated with his mother during the war. In the summer of 1955 he entered the Faculty of Physics of Moscow State University named after M. V. Lomonosov, but did not pass the competition. For a year he worked as a fitter at Mospodzemstroy. At the beginning of his career, he received the third, and then the fourth category, becoming a fairly qualified pipeline engineer, but even then he did not leave the idea of ​​​​entering Moscow University.

• In 1956 he entered the Faculty of Chemistry of Moscow State University named after M. V. Lomonosov. He was a student at the Department of Radiochemistry, engaged in the synthesis of radioprotectors (substances that protect against radiation). He completed his thesis on the topic "Reactions of 2,3-dibromopropanol with thiourea-35S"(supervisor - V. M. Fedoseev). He studied at the postgraduate course of the Department of Radiochemistry and in 1965 he defended his Ph.D. "Interaction of thiourea with some halide derivatives of the propane series"(scientific advisers, Doctor of Chemistry A. B. Silaev and Ph.D. V. M. Fedoseev).
• Finishing graduate school (), he received the position of senior laboratory assistant at the Institute of Chemistry of Natural Compounds of the USSR Academy of Sciences (the current Institute of Bioorganic Chemistry named after M. M. Shemyakin and Yu. A. Ovchinnikov RAS), where he worked at the same time until 1988. From 1988 to the present - Director of the Institute of Molecular Genetics of the USSR Academy of Sciences (since 1991 - RAS).
• At the moment, Academician E. D. Sverdlov is in charge of the Laboratory of the Structure and Function of Human Genes of the Institute of Bioorganic Chemistry. M. M. Shemyakin and Yu. A. Ovchinnikov RAS.
• In 2001, E. D. Sverdlov was awarded the title of full member of the German Academy of Sciences "Leopoldina", in 2002 - a member of the European Academy of Sciences.

Direction of scientific activity

• The main research is in the field of nucleic acid chemistry.
• In 1972, he proposed principles for studying the primary structure of DNA. Established (together with Yu. A. Ovchinnikov) the structures of genes encoding bacterial RNA polymerases (1981-1986). Established (1986, together with Yu. A. Ovchinnikov) the structures of the genes encoding Na, K-ATPase of animals, including humans. Found (1987) the multiplicity of ATPase genes and the tissue specificity of their expression.
• Since 1977 he has been engaged in genetic engineering developments. He cloned the genes encoding human interferon and obtained strains producing it, on the basis of which the industrial production of injectable interferon was created. Carries out work on the creation of genetically engineered antiviral vaccines. Investigates the influence of retroviruses on the speciation of primates (comparison of the genomes of higher primates).

Proceedings

• Kochetkov N.K., Budovsky E.I., Sverdlov E.D. et al. Organic chemistry of nucleic acids. M., 1970 (Translated into English: "Organic Chemistry of Nucleic Acids", 1971);
• Sverdlov E.D. Perpetually mobile footprints of ancient infections in human genome // FEBS Lett., 1998 May 22; 428(1-2): 1-6. review;
• Lapuk A.V., Khil P.P., Lavrentieva I.V., Lebedev Y.B., Sverdlov E.D. A human endogenous retrovirus-like (HERV) LTR formed more than 10 million years ago due to an insertion of HERV-H LTR into the 5" LTR of HERV-K is situated on human chromosomes 10, 19 and Y // J Gen Virol 1999 Apr;80(Pt 4):835-9;
• Sverdlov E.D. Retroviruses and primate evolution // Bioessays, 2000, Feb; 22(2): 161-71. Review;
• Vinogradova T.V., Sverdlov E.D. e.a. Solitary human endogenous retroviruses-K LTRs retain transcriptional activity in vivo, the mode of which is different in different cell // Virology. 2001 Nov 10;290(1):83-90.

ACADEMICIAN

Sverdlov Evgeny Davidovich

In 1961 he graduated from the Faculty of Chemistry of Moscow State University named after M. V. Lomonosov. He studied at the postgraduate course of the Department of Radiochemistry of the Faculty of Chemistry of Moscow State University, in 1965 he defended his thesis. In 1965 - 1998 researcher, head of the Group, head of the laboratory Institute of Bioorganic Chemistry. MM. Shemyakin and Yu.A. Ovchinnikov RAS.

In 1988 - 2006 - Director of the Institute of Molecular Genetics of the Russian Academy of Sciences.

Since 2006 Advisor to the Russian Academy of Sciences, Scientific Supervisor of the IMG RAS.

Specialist in bioorganic chemistry, molecular biology and genetics.

Corresponding Member since 1984, Academician of the Russian Academy of Sciences since 1997 – Department of Biological Sciences.

E. D. Sverdlov proposed principles for studying the primary structure of DNA. Established the structures of genes encoding bacterial RNA polymerases (1981-1986, together with Yu.A. Ovchinnikov). He discovered the multiplicity of ATPase genes and the tissue specificity of their expression (1987).

Since 1977 he has been engaged in genetic engineering developments. He cloned the genes encoding human interferon and obtained strains of these important biologically active compounds, on the basis of which their industrial production was created. He carries out work on the creation of genetically engineered antiviral vaccines.

Recently, he has been studying the effect of retroviruses on the speciation of primates (comparison of the genomes of higher primates).

A team of scientists from the Institute of Bioorganic Chemistry of the Russian Academy of Sciences under his leadership and with his direct participation for the first time in the world managed to completely map the 19th chromosome.

Editor-in-chief of the journal "Molecular Genetics, Microbiology and Virology". Member of the editorial boards of the journals "Bioorganic Chemistry", "International Journal of Genome".

Member of the Bureau of the Division of Biological Sciences of the Russian Academy of Sciences.

Member of the Bureau of the Scientific Council for Biotechnology of the Russian Academy of Sciences.

Member of the Council for Nanotechnology.

Head of the complex project of the project "Development and production of pilot batches of new effective directed-modified therapeutic and diagnostic means of post-genomic generation for use in oncological practice" of the federal target program "Research and development in priority areas of development of the scientific and technological complex of Russia for 2007-2012".

Academician of the Russian Academy of Agricultural Sciences (1991), full member of the German Academy of Sciences "Leopoldina", member of the European Academy of Sciences.

Member of the International Human Genome Organization (HUGO). Honorary Founder of the Science of Longevity Foundation.

Laureate of the Lenin and State Prizes.

He was awarded the Order of the Red Banner of Labor and the Order of Honor.

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IBCh named after M. M. Shemyakin and Yu. A. Ovchinnikov RAS

Evgeny Davidovich Sverdlov - Soviet and Russian biochemist, professor, corresponding member of the USSR Academy of Sciences, academician of the Russian Academy of Agricultural Sciences, full member of the Russian Academy of Sciences, Doctor of Chemical Sciences.

Biography

• Father - David Immanuilovich Sverdlov- an employee of the Central Committee of the Communist Party; mother - Yudif Markovna - a school teacher.
• In 1955 he graduated from high school with a silver medal in the Stavropol Territory, where he was evacuated with his mother during the war. In the summer of 1955 he entered the Faculty of Physics of Moscow State University named after M. V. Lomonosov, but did not pass the competition. For a year he worked as a fitter at Mospodzemstroy. At the beginning of his career, he received the third, and then the fourth category, becoming a fairly qualified pipeline engineer, but even then he did not leave the idea of ​​​​entering Moscow University.

• In 1956 he entered the Faculty of Chemistry of Moscow State University named after M. V. Lomonosov. He was a student of the Department of Radiochemistry, engaged in the synthesis of radioprotectors. He completed his thesis on the topic "Reactions of 2,3-dibromopropanol with thiourea-35S". He studied at the postgraduate course of the Department of Radiochemistry and in 1965 he defended his Ph.D. thesis on the topic “Interaction of thiourea with some halogen derivatives of the propane series”.
• Finishing graduate school, he received the position of senior laboratory assistant at the Institute of Chemistry of Natural Compounds of the USSR Academy of Sciences, where he worked at the same time until 1988. From 1988 to the present - Director of the Institute of Molecular Genetics of the USSR Academy of Sciences.
• At the moment, Academician E. D. Sverdlov is in charge of the Laboratory of the Structure and Function of Human Genes of the Institute of Bioorganic Chemistry. M. M. Shemyakin and Yu. A. Ovchinnikov RAS.
• In 2001, E. D. Sverdlov was awarded the title of full member of the German Academy of Sciences "Leopoldina", in 2002 - a member of the European Academy of Sciences.

Sagdeev, Renad Zinnurovich