How to grow crystals from penicillin. How to grow penicillin at home

In conditions of extreme survival, any wound can take months to heal, frostbite will definitely lead to gangrene, and mild inflammation can cause blood poisoning, so you can not even mention serious diseases such as pneumonia.

There is no misfortune from which this natural antibiotic with a very wide spectrum of action would not help. It will strengthen the immune system, and heal wounds with burns, frostbite and cracks, kill all types of fungi, even meat coated with this unique bee product can not deteriorate after a long stay in the scorching sun. Do you have a problem? Propolis will solve it. Therefore, if you find yourself in an extreme situation, you still decide to climb into the hive to the bees and take their honey, do not forget to grab propolis at the same time (when burning, it smells like incense). Depending on the localization of the disease, there are several ways to prepare medicines based on propolis at home:

Treatment with penicillin, the first antibiotic to be discovered and widely used at the turn of the last century, will either cure a bacterial infection or kill you if you are allergic to it. However, if you are far from the nearest settlement and become seriously ill (not a viral disease), this may be the only natural antibiotic that can still save your life.

The use of homemade penicillin at home is possible only in a really extreme situation.

Here's how to make homemade penicillin at home. No, we are not kidding!

Oranges and bread are the most common and affordable foods in the world. But did you know that they can easily grow penicillin?

To do this, just let them lie down - yes, yes, disgusting mold on stale bread is called "penicillium"!

Let's imagine what happened the zombie apocalypse. Running away from hungry monsters, your friend badly injured her leg.

The next day, sitting in a safe hiding place, you notice that the wound has clearly begun to become infected.

Considering that such an infection can lead to the loss of a leg and even death, how would you help a friend in the absence of modern medicine?

Here is an easy and cheap way to save a wounded comrade-in-arms:

  • Put a piece of bread in a bag or some other closed container.
  • Leave it to lie until spores begin to appear on it.
  • Then break it into small pieces.
  • Moisten them (sprinkle lightly with water) and put them back in the same closed container.
  • Keep an eye on the development of mold and do not remove it until most of the culture has acquired a characteristic green color.

The mold will go away as it grows. white, blue and green stage of development. Green mold is clearly visible in the photo above.

It is green mold that contains penicillin. As you can see, in the green areas, the mold is the most dense - this is the highest stage of development.

Option 1.

  • Crumble the bread and fill a large bowl with the crumbs.
  • Fill with warm water (not boiling water!).
  • Mix and drink daily until the penicillin works.

Note: keep in mind that bread will grow Not only mold. Not only will this potion taste nauseating, but it can easily cause an upset stomach. It is clear that in an emergency (such as a zombie apocalypse), diarrhea is a very reasonable price for getting rid of a dangerous infection. This remedy has been used in folk medicine for thousands of years.

  • Carefully scrape off only the green mold from the bread.
  • Wash the wound.
  • Cover the entire surface of the wound with pieces of mold.
  • Bandage with a bandage (not tight).
  • Repeat the procedure until you get the desired result.

Of course, in everyday life, you are unlikely to need homemade penicillin, given that it is widely available. In addition, modern medicine produces pharmaceutical grade penicillin, which is much safer.

But if a zombie apocalypse suddenly happens, you will have a better chance of surviving!

Penicillin

It is curious how dependent we are on society. Could an ordinary person help himself in 2010 to cope with a sore throat, pneumonia, sepsis, etc.? creating enough medicine without the risk of poisoning? I'm not a doctor, but I'll try to figure it out ...

Penicillin ( Benzylpenicillin) - the first antibiotic, that is, an antimicrobial drug obtained on the basis of the waste products of microorganisms.

Among the mushrooms widely distributed in nature, the most important for medicinal purposes are green racemose molds belonging to the genus of penicillium Penicillium, many species of which are capable of forming penicillin. For the production of penicillin, penicillin golden is used. This is a microscopic mushroom with a cloisonne branched mycelium that makes up the mycelium. On artificial nutrient media, it forms giant colonies. On the 12-14th day of growth on Czapek's agar medium, the colonies are velvety, 30-40 mm in diameter, sometimes with scattered aerial hyphae, greenish-bluish-blue, then green, with a white edge during the growth period; with age, acquiring a brownish tint, with abundant colorless or yellow drops of exudate on the surface. The reverse side of the colony is yellow or brownish-yellow. The surrounding agar turns yellow. Special hyphae develop on the mycelium - conidiophores, carrying spores. In the production of penicillin, only selected strains that do not form a yellow pigment are currently used. Most of these strains originate from a non-pigmented mutant of this species, obtained by the action of ultraviolet rays on a pigment-forming strain. Derivatives of this strain, obtained by exposure to ethyleneamine with subsequent selection, have the ability to give up to 3-4 thousand IU of penicillin in 1 ml of culture fluid. The morphological features of these strains are as follows: on the 12-14th day, the colony reaches 10-15 mm in diameter, strongly folded, convex or crater-shaped. The growing edge is very narrow and steep. A creamy-white colony with a slight greenish tint does not form, and the agar surrounding the colony is not stained. Mycelium thickened with short swollen cells.

Get penicillin as follows. The culture is carried out on media containing corn extract, which increases the yield of penicillin. The best carbohydrate for the culture fluid is lactose. The addition of phenylacetic acid and phenylacetamide at a concentration of 0.02-0.08% to the nutrient medium significantly increases the yield of penicillin, since these substances are included in the antibiotic molecule. Grow penicillin by the method of immersed cultures in special fermenters with a capacity of several tons. Penicillin is extracted from the culture fluid by successive treatment with organic solvents and slightly alkaline salt solutions, from which it then crystallizes in the form of sodium and potassium salts.

Active antimicrobial substances contained in the culture fluid of penicillin producers are a mixture of various penicillins. Different types of penicillin have the same main core and different side chains (radicals). All of them are heterocyclic compounds, the molecules of which are based on a bicyclic system built from fused thiazolidine and p-lactam rings. Currently, over 10 natural penicillins containing various radicals are known. Industrial (medical) penicillin contains mainly benzylpenicillin. Currently, in medical practice, it is also used phenoxymethylpenicillin (Penicillin - FAA), which is not destroyed by the influence of gastric juice and can be taken orally. Its predecessor is phenoxymethylacetic acid added to the culture medium.

Penicillin is a highly effective antibacterial agent widely used in medical practice for the treatment of diseases caused by streptococcus, staphylococcus, meningococcus, pneumococcus, gonococcus and other pathogenic aerobic bacteria. It is used in the form of sodium, potassium and other salts for sepsis and wound infection, pneumonia, acute and subacute septic endocarditis, purulent skin infection, septicemia and pyemia, osteomyelitis, tonsillitis, gonorrhea, syphilis and other diseases. The most effective intramuscular and intravenous administration of benzylpenicillin. It is also injected into serous cavities, joints, abscesses, fistulas in poliomyelitis; bandages impregnated with penicillin are applied to infected wounds, ulcers; it is recommended for rinsing and in the form of tablets for sore throats. Phenoxypenicillin is used in the form of tablets orally in the same cases as benzylpenicillin. Well-purified penicillins are practically non-toxic.

Preparations - crystalline penicillin (sodium and potassium salt of benzylpenicillin), penicillin - calcium salt, novocaine salt of penicillin, etc.

"Penicillin ceased to act on staphylococci more than 50 years ago - then penicillin-resistant strains appeared (the so-called PRSA - penicillin-resistant strains of Staphylococcus aureus or penicillin-resistant Staphylococcus aureus). So, at present, the vast majority of all strains of Staphylococcus aureus are resistant to penicillin. Over time, a number of other antibiotics have ceased to work on staphylococci - this microorganism has become resistant (resistant) to them. Such bacteria are called MRSA (methicillin-resistant Staphylococcus aureus - methicillin-resistant Staphylococcus aureus), and they are resistant to all antibiotics of the penicillin group, as well as same to a number of antibacterial drugs of other groups.

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Penicillin- the legendary drug. It started the era of antibiotics that saved millions of human lives. Until now, this tool is used in the treatment of certain infections. Today it is fashionable to scold antibiotics, attributing to them all conceivable and unthinkable shortcomings. But with the advent of penicillin, the world has changed forever and has certainly become a better place.

Who Discovered Penicillin?

At the beginning of the 20th century, an infection control agent became a necessity. The population grew, especially in industrial cities. And with such crowding, any infection threatened with a large-scale epidemic.

Scientists already knew a lot about bacteria, the causative agents of the most common and dangerous diseases were isolated and studied, and some drugs were also used. But a truly effective drug - did not exist.

At the end of the 20s of the last century (1881 - 1955) he actively studied pathogenic microorganisms, including staphylococcus, the cause of many diseases.

Discovery history

Literature, including fiction, colorfully describes that the Scottish scientist was careless and did not deactivate bacterial cultures immediately after working with them. And one day he noticed that the growing mold had dissolved the colonies in one of the Petri dishes.

You need to understand that it was not an ordinary mold, but brought in from a neighboring laboratory. It turned out that it belongs to the genus Penicillium (penicillum). There were doubts about its variety, but experts determined that it was penicillium notatum.

Fleming began growing this fungus in nutrient broth bottles and testing it. It turned out that even with a strong dilution, this antiseptic is able to suppress the growth and reproduction of not only staphylococcus, but also other pathogenic cocci (gonococcus, pneumococcus), diphtheria bacillus. At the same time, cholera virions, causative agents of typhoid and paratyphoid did not react to the action of penicillium notatum.

But the main questions were how to isolate a pure substance that destroys bacteria, how to preserve its activity for a long time? - There was no answer to them. Fleming tried to use the broth topically - for treating purulent wounds, for instillation into the eyes and nose (for rhinitis). But massive research has come to a standstill.

In the 40s, attempts to isolate pure penicillin were continued by the so-called Oxford Group of Microbiologists. Howard Walter Flory and Ernest Chain received a powder that could be diluted and injected.

Research was spurred on by the Second World War. In 1941, the Americans joined the research, who invented a more efficient technology for producing penicillin. This medicine was needed on the fronts, where any injury and even just an abrasion threatened blood poisoning and death.

The Soviet government approached the Allies for a new drug, but received no response. Then the Institute of Experimental Medicine began its own work, headed by Z. V. Ermolyeva. Several dozen variants of the Penicillium fungus were studied and the most active one was isolated - Penicillium crustosum. In 1943, domestic "penicillin-crustosin" began to be produced on an industrial scale.

This drug turned out to be more effective than the American one. Flory himself visited Moscow to see this. He, too, wanted to get the original culture of our antibiotic. They did not refuse him, but they gave him Penicillium notatum, already known in the West.

The modern concept of antibiotics

Antimicrobial drugs today are divided into many groups. According to the method of production, they are divided into:

  1. Biosynthetic - natural - they are isolated from cultures of microorganisms;
  2. Semi-synthetic - they are obtained by chemical modification of substances released by microorganisms.

The classification by chemical composition is widely used:

  • β-lactam - penicillin, cephalosporin, etc.;
  • Macrolides - erythromycin, etc.;
  • Tetracyclines and so on.

Antibiotics are also divided according to the spectrum of action: broad spectrum, narrow spectrum. By predominant effect:

  1. bacteriostatic - stop the division of bacteria;
  2. bactericidal - destroy adult forms of bacteria.

Modern penicillin and natural antibiotics

Today the ancestor of all antibiotics is called benzylpenicillin. It is a β-lactam natural bactericidal preparation. In its pure form, it does not have a wide spectrum of action. Some types of gram-negative bacteria, anaerobes, spirochetes and some other pathogens are sensitive to it.

It is to natural penicillins that most of the “claims” that they now like to make to all antibiotics can be attributed:

  1. They often cause allergies - immediate and delayed type reactions. Moreover, this applies to any means in which penicillin is present, including cosmetics and food products.
  2. The toxic effect of penicillins on the nervous system, mucous membranes (inflammation occurs), and kidneys are also described.
  3. When suppressing some microorganisms, others can multiply extremely. This is how superinfections arise - for example,.
  4. This medicine must be administered in injections - it is destroyed in the stomach. In addition, the drug is rapidly excreted, which requires frequent injections.
  5. Many strains of microorganisms have or develop resistance to its action. Often people who misuse antibiotics are to blame.

But it is important to understand that this (and wider) list of undesirable effects of penicillins appeared due to their excellent knowledge. All these shortcomings do not make this drug "poisonous" and do not cover the obvious benefits that it still brings to patients.

Suffice it to say that all international medical organizations have recognized the possibility of treating pregnant women with penicillin.

To expand the spectrum of action of a natural antibiotic, it is combined with substances that destroy the protection of bacteria - β-lactamase inhibitors (sulbactam, clavulonic acid, etc.). Forms of prolonged action have also been developed.

Modern semi-synthetic modifications help to overcome the shortcomings of natural penicillin.

Antibiotics of the penicillin group

Natural penicillins:

  • benzylpenicillin (penicillin G);
  • phenoxymethylpenicillin (penicillin V);
  • benzathine benzylpenicillin;
  • benzylpenicillin procaine;
  • benzathine phenoxymethylpenicillin.

Semi-synthetic penicillins:

Extended spectrum -

Against Pseudomonas aeruginosa -

  • Ticarcillin;
  • Azlocillin;
  • Piperacillin;

Against staphylococcus -

  • Oxacillin;

Combined with beta-lactamase inhibitors -

  • Ampicillin/sulbactam.

How to dilute penicillin

With each appointment of an antibiotic, the doctor must indicate the exact dose and dilution frequency. Attempts to "guess" them yourself will lead to dire consequences.

The dilution standard for penicillin is 100,000 IU per 1 ml of diluent (sterile water for injection or saline can serve). Different solvents are recommended for different preparations.

For the procedure, you will need 2 syringes (or 2 needles) - for dilution and for injection.

  1. Following the rules of asepsis and antisepsis, open the ampoule with the solvent and collect the required amount of liquid.
  2. Pierce the rubber cap of the penicillin powder vial with a 90-degree needle. The tip of the needle should show no more than 2 mm from the inside of the cap. Inject the solvent (required amount) into the vial. Disconnect the syringe from the needle.
  3. Shake the vial until the powder is completely dissolved. Put the syringe on the needle. Turn the vial upside down and draw the desired dose of medication into the syringe. Remove the vial from the needle.
  4. Change the needle to a new one - sterile, closed with a cap. Make an injection.

It is necessary to prepare the drug immediately before the injection - the activity of penicillin in the solution decreases sharply.

Surprisingly, but only a few years ago, the use of whiskey in cocktails was considered extremely bad taste. According to many tasters, this is a senseless spoilage of exquisite spirits, which are unique and beautiful only in their pure form.

However, time passed, and young bartenders went against the bigwigs of bar culture and with enviable regularity gave out amazing mixes, the alcoholic basis of which was whiskey. One of the most successful experiments was the Penicillin cocktail, invented by eminent New York bartender Sam Ross in 2005.

According to colleagues of the famous mixologist, he made a discovery and said a new word in the difficult task of creating alcoholic cocktails. Let's look at the difficult technology of preparing this alcoholic beverage.

The process of making the original mix from Sam Ross will not cause you any difficulties and problems. Follow the instructions exactly as described and you will be able to pleasantly surprise guests and loved ones with an indescribable taste and incomparable aroma of intoxicant.

According to the author of this spirit, special attention should be paid to the choice of whiskey, the main task of which is to balance and harmonize the rich aromas of honey and ginger - Scottish blended alcohol is best.

Also, pay attention to the order of the "assembly" of the mix: citrus fruits are laid first, then sweet ones, and finally - alcoholic components. Ice is added only last, as it quickly begins to melt and reduces the quality of the taste of the drink.

Required Ingredients

  1. First of all, let's prepare honey syrup. To do this, mix honey and water in an enamel pan in a ratio of 3: 1. Bring the liquid to a boil and boil over medium heat for at least 3 minutes, constantly and intensively stirring the mixture and removing the resulting foam from the surface. After that, remove the syrup from the heat and let it cool to room temperature naturally, while stirring the mass from time to time with a wooden spoon.
  2. Fresh ginger root is peeled and rubbed on a fine grater, after which we put the resulting slurry into a gauze cloth folded in 3-4 layers, and carefully squeeze the juice.
  3. We squeeze the lemon juice in any convenient way, after which we filter it through a gauze filter or a fine strainer.
  4. Now sequentially pour the ingredients into the shaker: first fresh lemon juice, then honey syrup, and then ginger juice.
  5. Shake the ingredients for 5-7 seconds.
  6. Add a couple of ice cubes and blended alcohol there.
  7. Shake the ingredients again for at least 10 seconds.
  8. The resulting liquid mixture is poured through a strainer directly into a chilled glass like rocks.
  9. Top with a thin stream of single malt alcohol and in no case stir the mix.
  10. Gently lower the remaining ice cubes and decoration in the form of a spiral of lemon peel into the hot water.
  11. We enjoy alcohol Penicillin through a straw, sipping the liquid in small sips.

Simplified Cocktail Recipe Penicillin

Not everyone is a fan of long and painstaking preparation of cocktails. For such cases, a simplified version of the Penicillin cocktail was invented, which anyone can repeat.

Required Ingredients

Manufacturing sequence

  1. Wash the lemon well and dry with a paper towel.
  2. Carefully cut a beautiful spiral from pure citrus to decorate the mix.
  3. Carefully squeeze the juice from a whole lemon, removing the seeds and pulp.
  4. Grate fresh ginger root in the required amount on a fine grater.
  5. Alternately put lemon juice, chopped ginger, ginger syrup and protein from one chicken egg into a shaker.
  6. Shake the ingredients very vigorously for at least 40 seconds.
  7. Open the shaker and add a couple of ice cubes and strong alcohol to it.
  8. Beat the mixture again for 20 seconds.
  9. Pour the finished alcoholic drink into a pre-chilled glass, filtering it through a strainer.
  10. Before direct tasting, we dip a couple of ice cubes into the liquid and decorate the hot drink with lemon zest.

Cocktail recipe Pink penicillin

Despite the rather sweet and innocent appearance, this mix is ​​known as one of the killer alcoholic drinks. This version of the popular spirit has a strong intoxicating effect, and not every consumer will stand on their feet and remain conscious after the second portion of this intoxicating drink. Therefore, carefully weigh everything and think it over before you start tasting the Pink Penicillin cocktail.

Required Ingredients

Manufacturing sequence

  1. Alternately pour schnapps, liquor, pomegranate syrup and blended whiskey into a shaker.
  2. We also lower a couple of ice cubes there and intensively shake the liquid ingredients for 15-20 seconds.
  3. Put the egg white, heavy cream into the blender bowl and beat the ingredients until airy and homogeneous.
  4. The resulting mixture is transferred to the shaker to the rest of the components and shake the shaker again for 10 seconds.
  5. Pour the finished alcoholic drink into a glass pre-chilled to an ice state.
  6. We also drop a couple of ice cubes there and decorate the mix with a thin circle of fresh lemon.

Cocktail recipe Tropical penicillin

This version of the legendary Penicillin also has a high strength and will be more to the liking of the strong half of humanity. Not everyone will be able to drink more than two servings without prior preparation. The finished alcoholic cocktail has a wonderful citrus flavor, woven with notes of sugary agave juice. The fragrance is also interesting because it has a complex bouquet of different smells.

Required Ingredients

Manufacturing sequence

  1. Fill a liquor glass to the top with ice cubes and set aside.
  2. Pour freshly squeezed lemon juice into a shaker, then orange, and then add ginger syrup.
  3. We also lower a couple of large ice cubes and salt there.
  4. We shake the contents of the shaker for at least 30 seconds so that the salt crystals will certainly dissolve in the liquid.
  5. Now it's time to add agave syrup and single malt whiskey to the shaker.
  6. Thoroughly mix the ingredients by vigorously shaking the shaker for another 30 seconds.
  7. We free the glass from ice and pour the finished alcoholic drink into it, passing it through a strainer or a fine sieve.
  8. We enjoy alcohol through a straw, savoring every sip.

Video of penicillin cocktail recipes

After getting acquainted with the presented videos, you will have the opportunity to follow the step-by-step technology for preparing the famous Penicillin mix. Each video highlights the author's recipe of experienced bartenders who have put a lot of effort into choosing the proportions and suitable brands of alcoholic ingredients and creating a cocktail that is really worth mentioning and tasting.

Video #1. Here is an almost classic version of the legendary Penicillin mix.

Video #2. In this video, some proportions have been changed, but the mix collection sequence remains unchanged. Also, a talented bartender will provide a wonderful, non-standard decoration for ginger-honey Penicillin.

Video #3. After reviewing this material, you will learn how to prepare a stunning Penicillin cocktail based on Scotch and lime fresh.

Helpful information

  • If you are a beginner in such a difficult business as bar art, then check out the recipes for the most popular “whiskey cocktails” that have become more and more popular lately.
  • Be sure to look at the technology of making the famous cocktail, which became the inspiration for Sam Ross, who made the mix discussed today.
  • Of course, I can't help but recommend the mafia mix, the favorite alcoholic drink of the famous Vito Corleone from the film of the same name directed by Francis Ford Coppola.
  • The last cocktail that I want to draw your attention to is called Old Fashion, the alcoholic base of which is rye whiskey.

In general, there is nothing difficult in creating a delicious and fragrant Penicillin cocktail. A little desire, a little effort, and those around you begin to smile more often, laugh more and thank you for your good mood.

Feel free to experiment with the ingredients, and if you manage to cook something worthwhile and worthy of attention, then by all means describe the recipe in the comments. I am very grateful for the time devoted to me and I wish you success in the difficult task of cocktail art!

I was interested in the question - is it possible to obtain antibiotics at home? Like penicillin?
Curious how much we depend on society??? Could an ordinary person help himself in 2010 to cope with a sore throat, pneumonia, sepsis, etc.? creating enough medicine without the risk of poisoning? I'm not a doctor, but I'll try to figure it out ...

Penicillin ( Benzylpenicillin) - the first antibiotic, that is, an antimicrobial drug obtained on the basis of the waste products of microorganisms.

Family Mucinaceae. Class imperfect mushrooms.
Among the mushrooms widely distributed in nature, the most important for medicinal purposes are green racemose molds belonging to the genus of penicillium Penicillium, many species of which are capable of forming penicillin. For the production of penicillin, penicillin golden is used. This is a microscopic mushroom with a cloisonne branched mycelium that makes up the mycelium. On artificial nutrient media, it forms giant colonies. On the 12-14th day of growth on Czapek's agar medium, the colonies are velvety, 30-40 mm in diameter, sometimes with scattered aerial hyphae, greenish-bluish-blue, then green, with a white edge during the growth period; with age, acquiring a brownish tint, with abundant colorless or yellow drops of exudate on the surface. The reverse side of the colony is yellow or brownish-yellow. The surrounding agar turns yellow. Special hyphae develop on the mycelium - conidiophores that carry spores. In the production of penicillin, only selected strains that do not form a yellow pigment are currently used. Most of these strains originate from a non-pigmented mutant of this species, obtained by the action of ultraviolet rays on a pigment-forming strain. Derivatives of this strain, obtained by exposure to ethyleneamine with subsequent selection, have the ability to give up to 3-4 thousand IU of penicillin in 1 ml of culture fluid. The morphological features of these strains are as follows: on the 12-14th day, the colony reaches 10-15 mm in diameter, strongly folded, convex or crater-shaped. The growing edge is very narrow and steep. A creamy-white colony with a slight greenish tint does not form, and the agar surrounding the colony is not stained. Mycelium thickened with short swollen cells.
Get penicillin as follows. The culture is carried out on media containing corn extract, which increases the yield of penicillin. The best carbohydrate for the culture fluid is lactose. The addition of phenylacetic acid and phenylacetamide at a concentration of 0.02-0.08% to the nutrient medium significantly increases the yield of penicillin, since these substances are included in the antibiotic molecule. Grow penicillin by the method of immersed cultures in special fermenters with a capacity of several tons. Penicillin is extracted from the culture fluid by successive treatment with organic solvents and slightly alkaline salt solutions, from which it then crystallizes in the form of sodium and potassium salts.
Active antimicrobial substances contained in the culture fluid of penicillin producers are a mixture of various penicillins. Different types of penicillin have the same main core and different side chains (radicals). All of them are heterocyclic compounds, the molecules of which are based on a bicyclic system built from fused thiazolidine and p-lactam rings. Currently, over 10 natural penicillins containing various radicals are known. Industrial (medical) penicillin contains mainly benzylpenicillin. Currently, in medical practice, it is also used phenoxymethylpenicillin (penicillin - FAA), which is not destroyed by the influence of gastric juice and can be taken orally. Its predecessor is phenoxymethylacetic acid added to the culture medium.
Penicillin is a highly effective antibacterial agent widely used in medical practice for the treatment of diseases caused by streptococcus, staphylococcus, meningococcus, pneumococcus, gonococcus and other pathogenic aerobic bacteria. It is used in the form of sodium, potassium and other salts for sepsis and wound infection, pneumonia, acute and subacute septic endocarditis, purulent skin infection, septicemia and pyemia, osteomyelitis, tonsillitis, gonorrhea, syphilis and other diseases. The most effective intramuscular and intravenous administration of benzylpenicillin. It is also injected into serous cavities, joints, abscesses, fistulas in poliomyelitis; bandages impregnated with penicillin are applied to infected wounds, ulcers; it is recommended for rinsing and in the form of tablets for sore throats. Phenoxypenicillin is used in the form of tablets orally in the same cases as benzylpenicillin. Well-purified penicillins are practically non-toxic.
Preparations - crystalline penicillin (sodium and potassium salt of benzylpenicillin), penicillin - calcium salt, novocaine salt of penicillin, etc.

Conclusion: At home, I won’t dare to do this ... out of dozens of varieties of the fungus, most are toxic ... it’s difficult to get the right one and clean it.

Curious ... about angina ... not sure of the authenticity
"Penicillin ceased to act on staphylococci more than 50 years ago - then penicillin-resistant strains appeared (the so-called PRSA - penicillin-resistant strains of Staphylococcus aureus or penicillin-resistant Staphylococcus aureus). So, at present, the vast majority of all strains of Staphylococcus aureus are resistant to penicillin.Over time, a number of other antibiotics have ceased to work on staphylococci - this microorganism has become resistant (resistant) to them.Such bacteria are called MRSA (methicillin-resistant Staphylococcus aureus - methicillin-resistant Staphylococcus aureus), and they are resistant to all antibiotics of the penicillin group, as well as same to a number of antibacterial drugs of other groups.

You can read very detailed and interesting here... Biological Encyclopedia Based on publications: "The Life of Animals" in 6 volumes (Publishing House "Prosveshchenie": M., 1970, edited by professors N.A. Gladkov, A.V. Mikheev) and "Life of Plants" in 6 volumes (Publishing house "Prosveshchenie", M., 1974, edited by A. L. Takhtadzhyan, editor-in-chief. Corresponding member of the Academy of Sciences of the USSR, prof. A. A. Fedorov).

In conditions of extreme survival, any wound can take months to heal, frostbite will definitely lead to gangrene, and mild inflammation can cause blood poisoning, so you can not even mention serious diseases such as pneumonia.

However, nature took good care of us, providing a wide range of natural antibiotics and healing herbs, the magical effect of which, unfortunately, today is known mainly only by shamans and village grannies.

Propolis

There is no misfortune from which this natural antibiotic with a very wide spectrum of action would not help. It will strengthen the immune system, and heal wounds with burns, frostbite and cracks, kill all types of fungi, even meat coated with this unique bee product can not deteriorate after a long stay in the scorching sun. Do you have a problem? Propolis will solve it. Therefore, if you find yourself in an extreme situation, you still decide to climb into the hive to the bees and take their honey, do not forget to grab propolis at the same time (when burning, it smells like incense). Depending on the localization of the disease, there are several ways to prepare medicines based on propolis at home:

Ointment: To make a medicinal ointment based on propolis, we need 100 g of any oily base for 15-20 g of propolis (olive or any other unrefined vegetable oil is best), after which the mixture must be boiled in a water bath for an hour, periodically stirring with a wooden wand. You can replace the oily base with butter by adding 5 ml of water, in which case the boiling time is reduced to 15 minutes. Before use, it is desirable to filter the solution through 2 layers of gauze. Store in a dark container, in a dark, cool place.

Tincture inside: Let 10 g of propolis brew in 100 ml of water (50 degrees C) during the day and you will get a pleasantly smelling yellowish aqueous solution with a shelf life of up to one week in a cool place. The daily safe dose is 2 tablespoons 4 times a day one hour before meals.

And may the power of the bees be with you.

Treatment with penicillin, the first antibiotic to be discovered and widely used at the turn of the last century, will either cure a bacterial infection or kill you if you are allergic to it. However, if you are far from the nearest settlement and become seriously ill (not a viral disease), this may be the only natural antibiotic that can still save your life.

How to get penicillin. Instruction: To get penicillin, you don’t have to go far, just open the refrigerator and find cheese with green mold, but it’s not a fact that this mold will be exactly a penicillin fungus, and even if it is, then the concentration of the antibiotic in it is unlikely to be enough for use in as a treatment for bacterial infections, otherwise in case of illness, doctors would simply stupidly prescribe eating mold. If there are no other options, and even magic propolis did not help you get penicillin, you can do the following:

Take a piece of bread or a slice of citrus and leave it to spoil in a 21 degree Celsius environment. After greenish-bluish mold appears, cut the bread or lemon into pieces, putting them in a pre-sterilized conical flask, in the dark at a temperature of 21 degrees Celsius, for five days.

It is very likely that after five days without antibiotics for a bacteriological disease, you are unlikely to need penicillin, however, nevertheless, prepare a nutrient medium for future mold colonies by dissolving the following ingredients in half a liter of cold water in the sequence indicated here: 44 g Lactose (you can replace with glucose, sucrose, etc., while ensuring their continuous supply), 25 g of corn starch, 3 g of sodium nitrate, 0.25 g of magnesium sulfate, 0.5 g of calcium monophosphate, 2.75 g of glucose monohydrate, 0.044 g of zinc sulfate and 0.044 of manganese sulfate. Now add cold water so that the total volume is 1 liter, and with perchloric acid adjust the pH of the culture between 5.0 and 5.5.

Pour the culture medium into bottles, such as milk bottles, sterilize them, then add a teaspoon of mold spores. To obtain penicillin, it remains only to let the bottles brew for 7 days, under the same conditions, after which the liquid with a nutrient medium is filtered and frozen as soon as possible to avoid decomposition of the already prepared penicillin.

It is better to treat with penicillin immediately and ONLY if there is no suitable alternative. As a strong antibiotic, it is able to overcome both blood poisoning and any bacteriological pathogen, however, one must be aware that the penicillin obtained by the above method will contain impurities of toxic molds, and it is very likely that these strains can slow down, and then completely prevent the release of penicillin, which will lead to an even greater bacteriological infection of your body. In addition, it should be borne in mind that penicillin is an allergen and in some people it can cause anaphylactic shock, which in extreme conditions is tantamount to death.